The Relationship of 5-Aminolevulinic Acid on Mood and Coping Ability in Prediabetic Middle Aged and Older Adults

by Rachael K. Aquino 1,*, Michael Perez 1, Payel Sil 2, Terry Shintani1, Rosanne Harrigan 1,† and

Beatriz Rodriguez1,3,*


  1. Department of Geriatrics and Department of Complementary and Alternative Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
  2. National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA
  3. Escuela de Medicina, Tecnologico de Monterrey, Monterrey, NL 64710, Mexico

In conclusion, we report that after 12 weeks of taking 5-ALA, self-perception of effort spent, loneliness, and coping ability were improved in a group of prediabetic middle aged and older adults. Improved mood and coping ability may allow prediabetic individuals to overcome the emotional obstacles preventing them from maintaining a healthy lifestyle and ultimately, help them stop the development of diabetes.

Supplementary Materials

The following are available at S1: Perceived Stress Scale, S2: Psychological Depressive Symptoms Questionnaire.


Strategic Business Innovator (SBI) Pharmaceuticals Co., Ltd. provided a contract to the John A. Burns School of Medicine at the University of Hawaii to conduct research studies. The natural supplement, 5-Aminolevulinic Acid (5-ALA), used in this study was provided by SBI Pharmaceuticals Co., Ltd. The investigators and authors had full control over the research studies and the present dissertation. The investigators from the University of Hawaii were partially supported by the grants from the National Institute on Minority Health and Health Disparities U54MD007584 and G12MD007601 from the National Institutes of Health.

Conflicts of Interest

Strategic Business Innovator (SBI) provided a contract to JABSOM to conduct the study. The investigators had full control over the study. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

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